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Stronger CYP3A4 inhibitors such as ketoconazole and itraconazole would be expected to have greater effects. Studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside in vitro. There is no safety information on the administration of sildenafil to patients with bleeding disorders or active peptic ulceration. Therefore sildenafil should be administered to these patients only after careful benefit-risk assessment. For some females with HDSS, Addyi can improve sexual desire and increase the number of sexually satisfying events.

Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. These events have been chosen for inclusion either due to their seriousness, reporting frequency, lack of clear alternative causation, or a combination of these factors. In placebo-controlled clinical studies, the discontinuation rate due to adverse reactions for VIAGRA (2.5%) was not significantly different from placebo (2.3%).

So, aside from keeping your Sildenafil close by or in your bedside draw, you don’t need to plan very far in advance before sex. This should give you the flexibility and peace of mind you need